Photocatalytic Synthesis of (Hetero)biaryls via Palladium-Catalyzed Hybrid-Radical Cross-Coupling of (Hetero)aryl Halides and C-H Functionalization of Heteroarenes

Light activates palladium catalysts to enable radical C-H (hetero)-arylation of heterocycles using simple (hetero)-aryl halides. Without the need of an external photocatalyst, the reaction proceeds under mild conditions with broad functional-group tolerance and high site selectivity, expanding photoactivated palladium catalysis for sustainable C-C bond formation in complex bi-(hetero)-aryl scaffolds.