STING Promotes Homeostasis via Regulation of Cell Proliferation and Chromosomal Stability

STING 通过调节细胞增殖和染色体稳定性来促进体内平衡

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作者:Diana Rose E Ranoa, Ryan C Widau, Stephen Mallon, Akash D Parekh, Claudia M Nicolae, Xiaona Huang, Michael J Bolt, Ainhoa Arina, Renate Parry, Stephen J Kron, George-Lucian Moldovan, Nikolai N Khodarev, Ralph R Weichselbaum

Significance

These findings provide clear mechanistic understanding of the role of STING in cell-cycle regulation, which may be exploited in cancer therapy because most normal cells express STING, while many tumor cells do not.See related commentary by Gius and Zhu, p. 1295.

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