Abstract
Solid-state structures, based on a Cambridge Structural Database (CSD) search, show that there is a C(α)N/C'O (cis) attraction in the torsional system O (cis) C'C(α)N of valine, causing a chirality chain. The C(α) configuration controls the chirality of the rotation around the C'-C(α) bond, which in turn induces a distortion of the planar unit C(α)C'(O)O to a flat asymmetric tetrahedron. Conformational "reactions" take place in an energy profile with respect to clockwise and counterclockwise rotation around the C'-C(α) bond as well as stretching and flattening of the tetrahedron. The molecular property C(α)N/C'O (cis) attraction of valine is maintained in its di- and tripeptides.