Abstract
BACKGROUND: Our study explores nosodes (potentized medicines derived from microbes), as alternative antimicrobial measures against infections. Different nosodes were tested for efficacy against pathogens in clinical urine samples, comparing them with Gentamicin. OBJECTIVE: Evaluating the efficacy of potentized medicines against microbes found in urine samples. MATERIALS AND METHODS: The test samples were added to the sterile 96 well plates with 150 μL of sterile media followed by bacteria-positive clinical urine samples (10 μL), and the plate was incubated at 37°C. After 72 h, optical density was measured. Reduction in bacterial growth was calculated as the antibacterial potential of the drugs. RESULTS: Escherichia coli poly-nosode 100C exhibited the highest efficacy at 93.79%, followed by Neisseria gonorrhoeae 100C (89.27%), E. coli 200C (79.61%), and Syphilinum 30C (78.76%) against Klebsiella pneumoniae. The average efficacy against Pseudomonas aeruginosa for the 27 test samples studied was 72.32%, (verses Gentamicin 74.25%). The highest efficacy at 92.79% was observed with E. coli poly-nosode followed by methicillin-resistant Staphyloccus aureus (MRSA) 30C (92.29%), N. gonorrhoeae 50C (92.29%), Cantharis 30C (90.95%), and Salmonella typhi 30C poly-nosode (81.35%). Cantharis 30C at 86.53% and E. coli 200C at 78.02% were effective against the mixed infection of E. coli + Candida albicans. The average efficacy of nosodes against this mixed infection was 63.53%, while Gentamicin demonstrated 61.97% efficacy. MRSA 100C showed the highest efficacy at 52.37% against E. coli, and an average efficacy of 44.5% was noted with test samples. CONCLUSIONS: Our study unveils the therapeutic potential of homeopathic medicines against antibiotic-resistant bacterial strains.