A community-led initiative to de-risk and advance Parkinson's disease therapeutic targets

一项由社区主导的倡议，旨在降低帕金森病治疗靶点的风险并推进其发展

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作者：Vaiana,Alexandra,Behr,Jonathan,Birol,Ryan,Blauwendraat,Cornelis,Casey,Bradford,Chowdhury,Kushan,Citron,Martin,Crapser,Joshua,Dardov,Victoria,Ducotterd,Fiona,Dumanis,Sonya,Dunlop,John,Durborow,Michelle,Fiske,Brian,Golden,Jessica,Hannestad,Jonas,Hung,Wendy,Kemp,Jennifer,Kleiman,Robin,Knight,Adam,Koemeter-Cox,Andrew,Leuchter,Bruce,Logsdon,Bejamin A,Marreiros,Rita,Miller,Julie E,Mitchell,Amanda,Mukherjee,Pooja,Navarro,Grace,Nelson,Matthew R,Nikolich,Karoly,Otis,Tom,Polinski,Nicole,Rastegar-Pouyani,Shima,Reith,Alastair D,Riley,Ekemini,Rubin,Lee,Ryten,Mina,Sadick,Jessica,Schwabe,Tina,Sherer,Todd,Silvergleid,Sarah,Singleton,Andrew,St Clair,Lara,Stoehr,Jan,Stone,David J,Sullivan,Julianna,Tanenbaum,Nicole,Tinelli,Elisa,Trimble,Kate,Wang,Yifei,Weninger,Stacie,Wiggenhauser,Nicolás,Wood,Stephen,Schoepp,Darryle,Buggia-Prevot,Virginie,Padmanabhan,Shalini,Skibinski,Gaia
期刊：Npj Parkinsons Disease影响因子：8.200
时间：2025起止号：2025 Jun 20;11(1):179
doi：10.1038/s41531-025-01039-3

Abstract

Identifying effective therapeutic targets for Parkinson's disease (PD) is challenging, with no current disease-modifying therapies available. To address this, The Michael J. Fox Foundation for Parkinson's Research launched the Targets to Therapies (T2T) initiative, uniting experts to prioritize and validate promising targets. T2T aims to develop validation strategies, create comprehensive target data profiles, and build tools to support drug development, ultimately accelerating the discovery of new therapies for PD patients.

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