日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A community-led initiative to de-risk and advance Parkinson's disease therapeutic targets

一项由社区主导的倡议,旨在降低帕金森病治疗靶点的风险并推进其发展

Vaiana, Alexandra; Behr, Jonathan; Birol, Ryan; Blauwendraat, Cornelis; Casey, Bradford; Chowdhury, Kushan; Citron, Martin; Crapser, Joshua; Dardov, Victoria; Ducotterd, Fiona; Dumanis, Sonya; Dunlop, John; Durborow, Michelle; Fiske, Brian; Golden, Jessica; Hannestad, Jonas; Hung, Wendy; Kemp, Jennifer; Kleiman, Robin; Knight, Adam; Koemeter-Cox, Andrew; Leuchter, Bruce; Logsdon, Bejamin A; Marreiros, Rita; Miller, Julie E; Mitchell, Amanda; Mukherjee, Pooja; Navarro, Grace; Nelson, Matthew R; Nikolich, Karoly; Otis, Tom; Polinski, Nicole; Rastegar-Pouyani, Shima; Reith, Alastair D; Riley, Ekemini; Rubin, Lee; Ryten, Mina; Sadick, Jessica; Schwabe, Tina; Sherer, Todd; Silvergleid, Sarah; Singleton, Andrew; St Clair, Lara; Stoehr, Jan; Stone, David J; Sullivan, Julianna; Tanenbaum, Nicole; Tinelli, Elisa; Trimble, Kate; Wang, Yifei; Weninger, Stacie; Wiggenhauser, Nicolás; Wood, Stephen; Schoepp, Darryle; Buggia-Prevot, Virginie; Padmanabhan, Shalini; Skibinski, Gaia

Aggrecan protects against plaque accumulation and is essential for proper microglial responses to plaques.

聚集蛋白聚糖可防止斑块积聚,并且对于小胶质细胞对斑块的正常反应至关重要。

Barahona Rocio A, Kwang Nellie E, Kono-Soosaipillai Aashna R, Rubio Salgado Giovanna, Tran Kristine M, Lu Yueh-Hao, Reddy Siddharth, da Cunha Celia, Velazquez-Rivera Eric, Crapser Joshua D, Xu Xiangmin, Hohsfield Lindsay A, Green Kim N

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies

恢复海马葡萄糖代谢可以改善阿尔茨海默病病理状态下的认知功能

Minhas, Paras S; Jones, Jeffrey R; Latif-Hernandez, Amira; Sugiura, Yuki; Durairaj, Aarooran S; Wang, Qian; Mhatre, Siddhita D; Uenaka, Takeshi; Crapser, Joshua; Conley, Travis; Ennerfelt, Hannah; Jung, Yoo Jin; Liu, Ling; Prasad, Praveena; Jenkins, Brenita C; Ay, Yeonglong Albert; Matrongolo, Matthew; Goodman, Ryan; Newmeyer, Traci; Heard, Kelly; Kang, Austin; Wilson, Edward N; Yang, Tao; Ullian, Erik M; Serrano, Geidy E; Beach, Thomas G; Wernig, Marius; Rabinowitz, Joshua D; Suematsu, Makoto; Longo, Frank M; McReynolds, Melanie R; Gage, Fred H; Andreasson, Katrin I

Degenerate mapping of environmental location presages deficits in object-location encoding and memory in the 5xFAD mouse model for Alzheimer's disease

在阿尔茨海默病5xFAD小鼠模型中,环境位置映射的退化预示着物体位置编码和记忆的缺陷。

Zhang, Hai; Chen, Lujia; Johnston, Kevin G; Crapser, Joshua; Green, Kim N; Ha, Nicole My-Linh; Tenner, Andrea J; Holmes, Todd C; Nitz, Douglas A; Xu, Xiangmin

Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R+/- mouse model of ALSP, which can be rescued via CSF1R inhibitors

小胶质细胞失衡导致 CSF1R+/- ALSP 小鼠模型中的神经元周围网络和突触丢失,可通过 CSF1R 抑制剂挽救

Miguel A Arreola, Neelakshi Soni, Joshua D Crapser, Lindsay A Hohsfield, Monica R P Elmore, Dina P Matheos, Marcelo A Wood, Vivek Swarup, Ali Mortazavi, Kim N Green

Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

脑室下区/白质小胶质细胞以动态波的形式重建空置的成人小胶质细胞微环境

Lindsay A Hohsfield ,Allison R Najafi ,Yasamine Ghorbanian ,Neelakshi Soni ,Joshua Crapser ,Dario X Figueroa Velez ,Shan Jiang ,Sarah E Royer ,Sung Jin Kim ,Caden M Henningfield ,Aileen Anderson ,Sunil P Gandhi ,Ali Mortazavi ,Matthew A Inlay ,Kim N Green

Subventricular zone/white matter microglia reconstitute the empty adult microglial niche in a dynamic wave

脑室下区/白质小胶质细胞以动态波的形式重建空置的成人小胶质细胞微环境

Lindsay A Hohsfield,Allison R Najafi,Yasamine Ghorbanian,Neelakshi Soni,Joshua Crapser,Dario X Figueroa Velez,Shan Jiang,Sarah E Royer ,Sung Jin Kim,Caden M Henningfield,Aileen Anderson ,Sunil P Gandhi,Ali Mortazavi,Matthew A Inlay ,Kim N Green

A Quantifiable Risk Factor for ACL Injury: Applied Mathematics to Model the Posterolateral Tibial Plateau Surface Geometry

前交叉韧带损伤的可量化风险因素:应用数学方法模拟胫骨平台后外侧表面几何形状

Tat, Jimmy; Crapser, Drew; Alaqeel, Motaz; Schupbach, Justin; Lee-Howes, Jacob; Tamimi, Iskandar; Burman, Mark; Martineau, Paul A

To Kill a Microglia: A Case for CSF1R Inhibitors

杀死小胶质细胞:CSF1R抑制剂的应用案例

Green, Kim N; Crapser, Joshua D; Hohsfield, Lindsay A

Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease

小胶质细胞耗竭可防止亨廷顿氏病模型中的细胞外基质变化和纹状体体积减少

Joshua D Crapser, Joseph Ochaba, Neelakshi Soni, Jack C Reidling, Leslie M Thompson, Kim N Green