Abstract
INTRODUCTION: Tobacco exposure is a leading modifiable risk factor for preventable deaths, harming the digestive system, and leading to a large number of deaths. METHODS: A secondary assessment of Global Burden of Disease (GBD) datasets was conducted. From 1990 to 2021, data on deaths from tobacco exposure on digestive diseases, including various genders and age groups, from the 2021 GBD Study were utilized. Trends across 204 countries/territories, 21 GBD, and 5 sociodemographic index (SDI) regions were analyzed. Additionally, a detailed analysis was conducted. Pearson correlation analysis, frontier analysis, age-period-cohort (APC) model, and the Bayesian APC (BAPC) model was utilized. RESULTS: From 1990 to 2021, the global number of deaths from tobacco-attributable digestive diseases decreased from 52789 (95% uncertainty interval (UI): 36999-68307) to 34061 (95% UI: 23821-46548). The age-standardized rate also decreased, from 1.34 (95% UI: 0.93-1.73) to 0.40 (95% UI: 0.28-0.55). Overall, SDI was negatively associated with disease burden, and the Quality of Care Index for digestive diseases increased with SDI. Results from the APC analysis showed that the mortality rate increased with age; more recently born cohorts had lower mortality rates at the same age; and the mortality rate across all age groups decreased over time. Predictions indicated that the death burden of tobacco-attributable digestive diseases will continue to decline for both males and females from 2022 to 2042. CONCLUSIONS: Global tobacco-attributable digestive diseases mortality may have decreased due to tobacco control and medical advances. The disease burden in older adults, males, and regions with middle to high SDI deserves special attention. Countries with a relatively high disease burden should learn from those with a lower burden among nations at the same SDI level regarding tobacco control and healthcare management.