Abstract
OBJECTIVE: To understand the current status, research hotspots, and trends of automatic segmentation of fundus lesion images worldwide, providing a reference for subsequent related studies. METHODS: The electronic database Web of Science Core Collection was searched for research in the field of automatic segmentation of fundus lesion images from 2007 to 2023. Visualization maps of countries, authors, institutions, journals, references, and keywords were generated and analyzed using the CiteSpace and VOSviewer software. RESULTS: After deduplication, 707 publications were sorted out, showing an overall increasing trend in publication volume. The countries with the highest publication counts were China, followed by India, the USA, the UK, Spain, Pakistan, and Singapore. A high degree of collaboration was observed among authors, and they cooperated widely. The keywords included "diabetic retinopathy," "deep learning," "vessel segmentation," "retinal images," "optic disc localization," and so forth, with keyword bursts starting in 2018 for "retinal images," "machine learning," "biomedical imaging," "deep learning," "convolutional neural networks," and "transfer learning." The most prolific author was U Rajendra Acharya from the University of Southern Queensland, and the journal with the most publications was Computer Methods and Programs in Biomedicine. CONCLUSIONS: Compared with manual segmentation of fundus lesion images, the use of deep learning models for segmentation is more efficient and accurate, which is crucial for patients with eye diseases. Although the number of related publications globally is relatively small, a growing trend is still witnessed, with broad connections between countries and authors, mainly concentrated in East Asia and Europe. Research institutions in this field are limited, and hence, the research on diabetic retinopathy and retinal vessel segmentation should be strengthened to promote the development of this area.