Dose-dependent immune response to Mycobacterium bovis BCG vaccination in neonates

新生儿对牛分枝杆菌卡介苗的剂量依赖性免疫反应

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Abstract

In 10-week-old infants vaccinated at birth with Japanese Mycobacterium bovis BCG, the number of dermal needle penetrations correlated positively with frequency of proliferating CD4(+) T cells in whole blood following BCG stimulation for 6 days but did not correlate with secreted cytokine levels after 7 h or interferon CD4(+) T-cell frequency after 12 h of BCG stimulation.

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