Abstract
The skin aging which entails modifications in the entire skin and skin support system is caused as a result of complex blend of intrinsic and extrinsic factors. The main objective of this review is to provide critical insights into the effect of the aging determinants (intrinsic and extrinsic) on aging skin and to focus on a few classes of natural bioactives that were reported to counteract symptoms of cutaneous aging, pose potential, and beneficial health effect on aging skin supported with relevant scientific evidence. The narrative review of this cutaneous antiaging study incorporating the literature findings was retrieved from the search of computerized databases PubMed and Scopus, hand searches, and authoritative books. The antiaging skin care approach of using bioactives are basically nutritional hormetins, available from our natural heritage, identified as potent free radical scavengers, antioxidants, moisturizers, cell repairing agents, and ultraviolet protectives which have started to seek considerable attention among researchers and consumers due to the undesirable effect of chemical-based constituents on human health and environment. With the booming antiaging strategies, beauty has become the prime factor in considering one's health and overall "wellness". As promoting healthy aging is essential, the objective of aesthetic dermatology should shift from cosmetic interventions to the betterment of quality of life of aging society. The paper also discusses on certain artificial learning/machine-based algorithms, useful in screening of bioactive ingredients, helpful in developing of more tailored formulations. This narrative overview on skin antiaging natural bioactives and artificial learning-based bioactive screening approaches contributes for the improvement in dermatological drug discovery, in the development of novel targeted lead compounds and accelerates aging research and pharmaceutical research.