Clinical care of pediatric patients with or at risk of postthrombotic syndrome: guidance from the ISTH SSC Subcommittee on pediatric and neonatal thrombosis and hemostasis

儿童血栓后综合征患者或有血栓后综合征风险患者的临床护理:ISTH SSC 儿童和新生儿血栓和止血小组委员会的指导意见

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Abstract

BACKGROUND/INTRODUCTION: Few risk models are specifically designed for adults with congenital heart disease. The GUCH and PEACH scores support personalized perioperative risk evaluation. The manual calculation of these scores is tedious; platforms like ChatGPT (CGPT) and DeepSek (DS) could help accelerate this process. PURPOSE: To determine the level of correlation between human assessment and the use of various artificial intelligence platforms for calculating risk scores in congenital heart surgery. METHODS: A Pearson correlation analysis was used to compare original and AI-assisted scoring systems. RESULTS: A total of 59 patients were analyzed. Mean age distribution was 32.7 ± 11.5 years. Weight (64.5 ± 16.2 kg), BMI (24.8 ± 4.9 kg/m²), and height (1.60 ± 0.10 m) followed near-normal distributions. The median of oxygen saturation was 95%. Hemoglobin levels (14.5 ± 2.8 g/dL) and ventricular ejection fractions (FEVD: 40.1 ± 10.6%, FEVI: 53.9 ± 12.6%) were normally distributed. Most patients were in NYHA class II (62.7%), followed by class III (22%) and only one patient in class IV. A correlation study was conducted to compare manually calculated congenital cardiac surgery risk scores (GUCH and PEACH) with those generated using artificial intelligence platforms CGPT 4.0 and DS. -GUCH vs. GUCH CGPT 4.0: Pearson correlation coefficient r = 0.31, p = 0.0174, indicating a weak but statistically significant positive correlation. -GUCH vs. GUCH DS: Pearson r = 0.708, p < 0.001, showing a strong and statistically significant positive correlation. -PEACH vs. PEACH CGPT 4.0: Pearson r = 0.37, p = 0.005, reflecting a moderate and statistically significant positive correlation. -PEACH vs. PEACH DS: Pearson r = 0.263, p = 0.041, demonstrating a weak but statistically significant positive correlation. DISCUSSION: The correlation analyses suggest varying degrees of agreement between the original scoring systems and their AI-assisted counterparts. The strong correlation between GUCH and GUCH DS (r = 0.708, p < 0.001) indicates a high degree of consistency, supporting the potential interchangeability or reliability of the DS-derived scores in this context. Conversely, the weaker correlations observed with CGPT 4.0 versions of both GUCH (r = 0.31) and PEACH (r = 0.37), though statistically significant, imply that these models capture overlapping but not identical constructs or decision patterns. The modest association between PEACH and PEACH DS (untrained) (r = 0.263) further highlights the variability introduced by untrained scoring systems and underscores the importance of calibration or training in improving concordance. CONCLUSION: The findings highlight the potential of AI-assisted tools in replicating manually calculated risk scores, with varying levels of accuracy. DeepSek, in particular, demonstrated strong agreement with manual GUCH scores. However, these tools require further validation and refinement before being adopted in clinical practice. [Figure: see text]

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