Abstract
Predicting the fatigue lifespan of Twisted String Actuators (TSAs) is essential for improving the reliability of robotic and mechanical systems that rely on flexible transmission mechanisms. Traditional empirical approaches based on regression or Weibull distribution analysis have provided useful approximations, yet they often struggle to capture nonlinear dependencies and stochastic influences inherent to real-world fatigue behavior. This study introduces and compares four machine learning (ML) models-Linear Regression, Random Forest, XGBoost, and Gaussian Process Regression (GPR)-for predicting TSA lifespan under varying weight (W), number of strings (N), and diameter (D) conditions. Building upon this comparison, a hybrid physics-guided model is proposed by integrating an empirical fatigue life equation with an XGBoost residual-correction model. Experimental data collected from repetitive actuation tests (144 valid samples) served as the basis for training and validation. The hybrid model achieved an R(2) = 0.9856, RMSE = 5299.47 cycles, and MAE = 3329.67 cycles, outperforming standalone ML models in cross-validation consistency (CV R(2) = 0.9752). The results demonstrate that physics-informed learning yields superior interpretability and generalization even in limited-data regimes. These findings highlight the potential of hybrid empirical-ML modeling for component life prediction in robotic actuation systems, where experimental fatigue data are scarce and operating conditions vary.