Abstract
The pathogenesis of autoimmune diseases remains unclear, which is associated with T helper (Th) cell subsets such as Th1, Th2, Treg and Tfh cells. Recent studies have indicated the involvement of N(6)-methyladenosine (m(6)A) modification in the pathogenesis of autoimmune diseases, and m(6)A also affects the differentiation, and function of Th cells. However, few reports focused on the relationship between m(6)A modification in Th cell subsets and autoimmune diseases. This review summarizes the latest research progress on m(6)A modification in common autoimmune diseases, specifically highlighting how various m(6)A-modifying enzymes influence the differentiation and function of Th cells and disease progression. Elucidating the relationship between m(6)A modification and Th cells in autoimmune diseases may provide a new perspective for disease prevention and targeted therapy. Finally, this review also elaborates on the impact of m(6)A on the clinical diagnosis and treatment of autoimmune diseases, as well as the challenges that need to be addressed.