Abstract
Brain edema is one of the most devastating consequences of acute ischemic stroke, but an effective and preventive therapy targeting the formation of ischemic brain edema has not yet to be validated. Ischemic brain edema is primarily caused by damage to the blood-brain-barrier, leading to the leakage of ions and water into the brain tissue. Ion channels and transporters play a crucial role in ischemic brain edema. Understanding their function and regulation mechanism could provide valuable insights into new therapeutic targets for ischemic brain edema. Recently, significant progress has been made in the study about ion channels and transporters as therapeutic targets for ischemic brain edema. In this review, we summarize ion channels and transporters involved in the formation of ischemic brain edema, including trigger force, physiological function, regulatory mechanisms, and detection technologies. Especially, we will focus on the roles of these ion channels and transporters in ischemic brain edema, as well as recent advances in therapeutic strategies targeting these transporters.