Abstract
PURPOSE: To explore the relationship between the systemic immune-inflammation index (SII) and deep venous thrombosis (DVT) in patients with spinal cord injury (SCI). METHODS: This cross-sectional study included data from 382 participants with SCI. The SII was calculated for all participants. Logistic regression, smooth curve fitting, interaction effects were used to substantiate the research objectives. RESULTS: The overall prevalence of DVT was 23.1% (22.4% among males, 25.6% among females). A positive association between SII and the risk for DVT was observed (odds ratio 1.39 [95% CI 1.03-1.87]; P=0.032), independent of confounders. Similar patterns of association were observed in the subgroup analysis (P values for interaction, all >0.05). Further sensitivity analyses provided confidence that the results were reliable and unlikely to be substantially altered by unmeasured confounding factors. CONCLUSION: Results of the present suggest that higher SII may be associated with DVT in patients with SCI, highlighting a potential link between SII and DVT. These findings underscore the potential of SII as a valuable predictive biomarker for DVT, thus offering a promising avenue for early detection and intervention strategies in patients with SCI.