Human Tumor-Associated Macrophages and Neutrophils Regulate Antitumor Antibody Efficacy through Lethal and Sublethal Trogocytosis

人类肿瘤相关巨噬细胞和中性粒细胞通过致死和亚致死吞噬作用调节抗肿瘤抗体功效

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作者:Sunil Singhal, Abhishek S Rao, Jason Stadanlick, Kyle Bruns, Neil T Sullivan, Andres Bermudez, Adam Honig-Frand, Ryan Krouse, Sachinthani Arambepola, Emily Guo, Edmund K Moon, George Georgiou, Thomas Valerius, Steven M Albelda, Evgeniy B Eruslanov

Significance

The elucidation of the conditions and mechanisms by which human FcR+ myeloid effectors mediate cancer cell resistance and killing during antibody treatment could help develop improved strategies for treating solid tumors.

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