Genome-wide meta-analysis identifies new susceptibility loci for migraine

全基因组荟萃分析发现了偏头痛的新易感基因位点

阅读：1
作者：Anttila,Verneri,Winsvold,Bendik S,Gormley,Padhraig,Kurth,Tobias,Bettella,Francesco,McMahon,George,Kallela,Mikko,Malik,Rainer,de Vries,Boukje,Terwindt,Gisela,Medland,Sarah E,Todt,Unda,McArdle,Wendy L,Quaye,Lydia,Koiranen,Markku,Ikram,M Arfan,Lehtimäki,Terho,Stam,Anine H,Ligthart,Lannie,Wedenoja,Juho,Dunham,Ian,Neale,Benjamin M,Palta,Priit,Hamalainen,Eija,Schürks,Markus,Rose,Lynda M,Buring,Julie E,Ridker,Paul M,Steinberg,Stacy,Stefansson,Hreinn,Jakobsson,Finnbogi,Lawlor,Debbie A,Evans,David M,Ring,Susan M,Färkkilä,Markus,Artto,Ville,Kaunisto,Mari A,Freilinger,Tobias,Schoenen,Jean,Frants,Rune R,Pelzer,Nadine,Weller,Claudia M,Zielman,Ronald,Heath,Andrew C,Madden,Pamela A F,Montgomery,Grant W,Martin,Nicholas G,Borck,Guntram,Göbel,Hartmut,Heinze,Axel,Heinze-Kuhn,Katja,Williams,Frances M K,Hartikainen,Anna-Liisa,Pouta,Anneli,van den Ende,Joyce,Uitterlinden,Andre G,Hofman,Albert,Amin,Najaf,Hottenga,Jouke-Jan,Vink,Jacqueline M,Heikkilä,Kauko,Alexander,Michael,Muller-Myhsok,Bertram,Schreiber,Stefan,Meitinger,Thomas,Wichmann,Heinz Erich,Aromaa,Arpo,Eriksson,Johan G,Traynor,Bryan,Trabzuni,Daniah,Rossin,Elizabeth,Lage,Kasper,Jacobs,Suzanne B R,Gibbs,J Raphael,Birney,Ewan,Kaprio,Jaakko,Penninx,Brenda W,Boomsma,Dorret I,van Duijn,Cornelia,Raitakari,Olli,Jarvelin,Marjo-Riitta,Zwart,John-Anker,Cherkas,Lynn,Strachan,David P,Kubisch,Christian,Ferrari,Michel D,van den Maagdenberg,Arn M J M,Dichgans,Martin,Wessman,Maija,Smith,George Davey,Stefansson,Kari,Daly,Mark J,Nyholt,Dale R,Chasman,Daniel,Palotie,Aarno
期刊：Nature Genetics影响因子：29.000
时间：2013起止号：2013 Aug;45(8):912-917
doi：10.1038/ng.2676研究方向： 神经科学
疾病类型： 偏头痛

Abstract

Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用；引用内容仅为补充信息，不代表本站立场。

2、若认为本页面引用内容涉及侵权，请及时与本站联系，我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容，需注明“来源：[生知库]”并获得授权；使用引用内容的，需自行联系原作者获得许可。

4、投稿及合作请联系：info@biocloudy.com。