Abstract
The research of interactions between the pathogens and their hosts is key for understanding the biology of infection. Commencing on the level of individual molecules, these interactions define the behavior of infectious agents and the outcomes they elicit. Discovery of host-pathogen interactions (HPIs) conventionally involves a stepwise laborious research process. Yet, amid the global pandemic the urge for rapid discovery acceleration through the novel computational methodologies has become ever so poignant. This review explores the challenges of HPI discovery and investigates the efforts currently undertaken to apply the latest machine learning (ML) and artificial intelligence (AI) methodologies to this field. This includes applications to molecular and genetic data, as well as image and language data. Furthermore, a number of breakthroughs, obstacles, along with prospects of AI for host-pathogen interactions (HPI), are discussed.