Abstract
Long non-coding RNAs (LncRNA) have been wildly explored in several malignant tumors. This study aimed to evaluate the effect of HOXA11-AS polymorphisms (rs17427875 and rs11564004) on lung cancer susceptibility and its interaction with smoking exposure. This hospital-based case-control study, which included 466 cases and 557 controls, was carried out in Shenyang City, Liaoning province. The genotyping method was TaqMan allelic discrimination assay and all statistical analysis were performed by SPSS 20.0 and R (3.5.3). The results demonstrated that HOXA11AS-rs17427875 polymorphisms were correlated with the susceptibility of lung adenocarcinoma. T alleles of rs17427875 played a portal role in increasing lung adenocarcinoma risk. HOXA11AS-rs11564004 polymorphisms had the significant association with lung cancer risks, as well as its subtypes like non-small cell lung cancer, adenocarcinoma. The allele G of rs11564004 acted as a protective factor for lung cancer. The similar results were observed in the homozygous model and recessive model of rs11564004. Nevertheless, interaction analysis of the additive and multiplicative model scales showed no statistical significance between HOXA11-AS polymorphisms and smoking exposure in the development of lung cancer.