Adoptive immunotherapy with engineered T cells expressing and HLA-A2 restricted affinity-enhanced TCR for LAGE-1 and NY-ESO-1 in patients with multiple myeloma following auto-SCT

在接受自体干细胞移植后，对多发性骨髓瘤患者进行过继性免疫治疗，采用表达HLA-A2限制性亲和力增强的LAGE-1和NY-ESO-1靶向T细胞受体（TCR）的工程化T细胞。

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作者：Metzger,Philipp,Kirchleitner,Sabrina V,Kluge,Michael,Koenig,Lars M,Hörth,Christine,Rambuscheck,Carlotta A,Böhmer,Daniel,Ahlfeld,Julia,Kobold,Sebastian,Friedel,Caroline C,Endres,Stefan,Schnurr,Max,Duewell,Peter,de Gruijl,Tanja D,Koster,Bas D,van den Hout,Mari FCM,Sluijter,Berbel JR,Molenkamp,Barbara G,Vuylsteke,Ronald JCLM,van Leeuwen,Paul AM,Scheper,Rik J,van den Tol,Petrousjka,van den Eertwegh,Alfons,Rizvi,Naiyer,Chaft,Jamie,Balmanoukian,Ani,Goldberg,Sarah B,Sanborn,Rachel E,Steele,Keith E,Rebelatto,Marlon C,Gu,Yu,Karakunnel,Joyson J,Antonia,Scott,Chen,Yu,Zhou,Zhi-feng,Zhu,Wei-feng,Chen,Gang,Shi,Yi,Lin,Wan-song,Guo,Zeng-qing,Ye,Yun-bin,Page,David B,McArthur,Heather,Dong,Zhiwan,Wong,Phillip,Emerson,Ryan,Mu,Zhenyu,Zhao,Chunjun,Comstock,Christopher,Morris,Elizabeth,Comen,Elizabeth,Kotin,Alan,Sung,Janice,Brogi,Edi,Morrow,Monica,Solomon,Stephen,Sacchini,Virgilio,Maybody,Majid,Neville,Deirdre,Diab,Adi,Sharma,Padmanee,Robins,Harlan,Patil,Sujata,Wolchok,Jedd D,Hudis,Clifford,Norton,Larry,Allison,James,Yuan,Jianda,Rosario,Maximillian,Liu,Bai,Kong,Lin,Schneider,Stephanie E,Jeng,Emily K,Rhode,Peter R,Wong,Hing C,Fehniger,Todd A,Hodi,F Stephen,Ribas,Antoni,Daud,Adil,Hamid,Omid,Robert,Caroline,Kefford,Richard,Hwu,Wen-Jen,Gangadhar,Tara C,Joshua,Anthony M,Hersey,Peter,Weber,Jeffrey,Joseph,Richard W,Zarour,Hassane,Dronca,Roxana,Gammage,Linda,Hille,Darcy,Xue,Dahai,Kang,S Peter,Chun,Patrick,Ebbinghaus,Scot W,Perrone,Andrea,Wolchok,Jedd D,van de Ven,Rieneke,van Pul,Kim,Aliabadi,Shaghayegh,van den Tol,M Petrousjka,Haley,Daniel,Tamakawa,Raina,Vuylsteke,Ronald J,Stockmann,Hein B,Cramer,Julie L,Urba,Walter J,Fox,Bernard A,de Gruijl,Tanja D,Ohkuri,Takayuki,Ghosh,Arundhati,Kosaka,Akemi,Zhu,Jianzhong,Ikeura,Maki,David,Michael,Watkins,Simon C,Sarkar,Saumendra N,Okada,Hideho,Rapoport,Aaron P,Stadtmauer,Edward A,Vogl,Dan T,Weiss,Brendan,Binder-Scholl,Gwendolyn K,Smethurst,Dominic P,Finklestein,Jeffrey,Kulikovskaya,Irina,Gupta,Minnal,Brewer,Joanna E,Bennett,Alan D,Gerry,Andrew B,Pumphrey,Nick J,Tayton-Martin,Helen K,Ribeiro,Lilliam,Badros,Ashraf Z,Yanovich,Saul,Akpek,Gorgun,Kerr,Naseem,Philip,Sunita,Westphal,Sandra,Bruce,Levine L,Jakobsen,Bent K,June,Carl H,Kalos,Michael
期刊：Journal for ImmunoTherapy of Cancer影响因子：10.600
时间：2013起止号：2013;1(Suppl 1):P30
doi：10.1186/s40425-019-0830-7研究方向： 信号转导、免疫/内分泌、发育与干细胞、细胞生物学
疾病类型： 骨髓瘤、多发性骨髓瘤细胞类型： T细胞、干细胞

Abstract

Following publication of the original article [1], the authors have reported that Fig. 2 and Additional file 1: Figure S1, S2 partially show red scripts.

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