Cerebrospinal fluid level of proNGF as potential diagnostic biomarker in patients with frontotemporal dementia
脑脊液中 proNGF 水平作为额颞叶痴呆患者的潜在诊断生物标志物
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作者：Francesca Malerba, Rita Florio, Ivan Arisi, Chiara Zecca, Maria Teresa Dell'Abate, Giancarlo Logroscino, Antonino Cattaneo
| 期刊： | Frontiers in Aging Neuroscience | 影响因子： | 4.100 |
| 时间： | 2024 | 起止号： | 2024 Jan 25:15:1298307. |
| doi： | 10.3389/fnagi.2023.1298307 | 种属： | Goat |
| 方法学： | ELISA、WB | 靶点： | IgG |
| 研究方向： | 神经 | 疾病类型： | 阿尔茨海默症 |
Discussion
These results suggest that proNGF could be included in a panel of biomarkers to improve the FTD diagnosis.
Methods
By the means of a new immunoassay, we have measured and analyzed the proNGF levels in 43 cerebrospinal fluids (CSF) from FTD patients, and compared the
Results
A statistically significant difference between proNGF levels in FTD compared to AD, SMC and controls subjects was found. The statistical models reveal that proNGF determination increases the accuracy of FTD diagnosis, if added to the clinically validated CSF biomarkers.
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