Abstract
OBJECTIVE: To investigate the impact of different early enteral nutrition (EEN) strategies on nutritional indicators and immune function in patients with acute kidney injury (AKI) undergoing continuous renal replacement therapy (CRRT). METHODS: A retrospective analysis was conducted on 60 CRRT-treated AKI patients from January 2020 to March 2024, divided into a control group (high-energy EEN) and an observation group (low-energy EEN). Nutritional indicators (albumin, prealbumin, hemoglobin), immune function indicators (CD4+, CD8+, immunoglobulin A, G, M), and clinical outcomes (ICU stay duration, CRRT duration, gastric retention) were compared. RESULTS: Before treatment, there were no significant differences in nutritional indicators between the two groups (P > 0.05). After 7 days of treatment, the observation group showed significantly greater improvements in all nutritional indicators (P < 0.05). Immune function indicators also improved significantly in the observation group (P < 0.05). Additionally, the observation group had significantly shorter ICU and CRRT durations compared to the control group (P < 0.05). CONCLUSION: Compared to high-energy EEN guidance, low-energy EEN guidance significantly improves nutritional status and enhances immune function in CRRT-treated AKI patients.