Abstract
PURPOSE: Subjective cognitive decline (SCD) is the earliest symptom stage of Alzheimer's disease (AD), and the APOEε4 allele is the strongest genetic risk factor for sporadic AD. Based on graph theory, the resting state functional connectivity (rsFC) in SCD patients with APOEε4 was studied to explore the effect of APOEε4 on the rsFC network properties of SCD patients. PATIENTS AND METHODS: This cross-sectional study included MRI image data from 19 SCD patients with APOEε4 (SCD+), 29 SCD patients without APOEε4 (SCD-), and 30 normal control (NC-) individuals without APOEε4. We generated a binary matrix based on anatomical automatic labeling (AAL) 90 atlas to construct the functional network. We then calculated the whole brain network characteristics and intracerebral node characteristics by graph theory. RESULTS: For the whole brain network characteristics, all three groups showed small-worldness. The SCD+ group had increased compensatory information transfer speed and enhanced integration capability. This group also had high heterogeneity for intracerebral node characteristics, mainly in the default mode network, left superior occipital gyrus, and bilateral putamen. CONCLUSION: APOEε4 effects the functional brain network in patients with SCD and may be a potential indicator for the identification of SCD.