YAP1 and COX2 Coordinately Regulate Urothelial Cancer Stem-like Cells

YAP1和COX2协同调控尿路上皮癌干细胞样细胞

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作者:Akira Ooki, Maria Del Carmen Rodriguez Pena, Luigi Marchionni, Wikum Dinalankara, Asma Begum, Noah M Hahn, Christopher J VandenBussche, Zeshaan A Rasheed, Shifeng Mao, George J Netto, David Sidransky, Mohammad O Hoque

Significance

These findings offer a preclinical rationale to target the COX2 and YAP1 pathways concurrently with systemic chemotherapy to improve the clinical management of UCB, based on evidence that these two pathways expand cancer stem-like cell populations that mediate resistance to chemotherapy. Cancer Res; 78(1); 168-81. ©2017 AACR.

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