Abstract
PURPOSE: To analyze Bruch's membrane opening minimum rim width (BMO-MRW) for detecting glaucoma in patients with myopia < -6D and assessment of peripapillary retinal nerve fiber layer thickness (pRNFLT). METHODS: One eye was randomly selected from each of the 90 subjects (A-30 normal controls, B-30 with glaucoma suspect, and C-30 with primary open-angle glaucoma [POAG]). All patients underwent baseline ophthalmic evaluation. BMO- MRW and pRNFLT data were obtained using spectral-domain optical coherence tomography (Spectralis, Heidelberg Engineering GmbH, Heidelberg, Germany). The area under the receiver operating characteristic curves (AUC) for global and sectoral thickness parameters was calculated. RESULTS: Sectoral analysis of BMO-MRW for the discrimination of early glaucoma in all myopic subjects showed significantly better diagnostic performance than pRNFLT in temporal (0.85 (0.77 to 0.94) P = 0.014), temporal superior (TS) (0.90 (0.83 to 0.98) P = 0.005), and nasal inferior quadrants (0.92 (0.86 to 0.97) P = 0.022) with 95% CI. When discriminating early glaucoma from the suspect, overall the diagnostic performance of BMO-MRW was higher than that of pRNFLT, with significant differences in the temperosuperior quadrant (0.85 (0.74 to 0.95) 95% CI, P = 0.047). CONCLUSION: BMO-MRW had better diagnostic performance than RNFL thickness and is a useful parameter for detecting glaucoma in myopic eyes (≤-6D) with POAG.