γ-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo

γ 射线通过增加体内和体外癌睾丸抗原的表达来促进癌细胞的免疫识别

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作者:Anu Sharma, Beata Bode, Roland H Wenger, Kuno Lehmann, Alessandro A Sartori, Holger Moch, Alexander Knuth, Lotta von Boehmer, Maries van den Broek

Background

γ-radiation is an effective treatment for cancer. There is evidence that radiotherapy supports tumor-specific immunity. It was described that irradiation induces de novo protein synthesis and enhances antigen presentation, we therefore investigated whether γ-radiation

Conclusions

Our findings suggest that γ-radiation promotes the immunological recognition of the tumor. We therefore propose that combining radiotherapy with treatments that support tumor specific immunity may result in increased therapeutic efficacy.

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