Oleanolic acid initiates apoptosis in non-small cell lung cancer cell lines and reduces metastasis of a B16F10 melanoma model in vivo
齐墩果酸启动非小细胞肺癌细胞系的细胞凋亡并降低体内B16F10黑色素瘤模型的转移
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作者:Kelly Araújo Lúcio, Gleice da Graça Rocha, Leonardo Campos Monção-Ribeiro, Janaina Fernandes, Christina Maeda Takiya, Cerli Rocha Gattass
| 期刊: | PLoS One | 影响因子: | 2.900 |
| 时间: | 2011 | 起止号: | 2011;6(12):e28596. |
| doi: | 10.1371/journal.pone.0028596 | 研究方向: | 信号转导、细胞生物学、肿瘤 |
| 疾病类型: | 肺癌、黑色素瘤 | 细胞类型: | 肿瘤细胞 |
| 信号通路: | Apoptosis | |
Background
Drug resistance, a process mediated by multiple mechanisms, is a critical determinant for treating lung cancer. The
Conclusion
Our data provide a significant insight into the antitumoral and antimetastatic activity of OA in NSCLC and suggest that including OA in the NSCLC regimens may help to decrease the number of relapses and reduce the development of metastases.
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