Wnt/planar cell polarity signaling in the regulation of convergent extension movements during Xenopus gastrulation

Wnt/平面细胞极性信号在非洲爪蟾原肠胚形成过程中对收敛伸展运动的调节

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作者:Gun-Hwa Kim, Edmond Changkyun Park, Jin-Kwan Han

Abstract

The Wnt/planar cell polarity (PCP) signaling pathway plays a critical role in wing, eye, neural tube defects, and sensory bristle development of Drosophila and vertebrate development. Recently, the Wnt/PCP pathway has been known to regulate convergent extension (CE) movements that are essential for establishing the three germ layers and body axis during early vertebrate development. Here, we describe detailed practical procedures required for the particular studies in Xenopus CE movements.

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