Generation of iPSC line (FAMRCi009-A) from patient with familial progressive cardiac conduction disorder carrying genetic variant FLNC p.Val2264Met

从携带遗传变异 FLNC p.Val2264Met 的家族性进行性心脏传导障碍患者中生成 iPSC 系 (FAMRCi009-A)

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作者:Nataliia Rodina, Aleksandr Khudiakov, Kseniya Perepelina, Aleksey Muravyev, Aleksandr Boytsov, Anna Zlotina, Polina Sokolnikova, Anna Kostareva

Abstract

Human iPSC cell line FAMRCi009-A was generated from a patient with restrictive cardiomyopathy and congenital myopathy carrying FLNC p.Val2264Met genetic variant. Patient-specific peripheral blood mononuclear cells were reprogrammed using non-integrative Sendai viruses. Generated iPSC lines showed normal karyotype, expressed pluripotency markers and exhibited trilineage differentiation potential in vitro. The reported iPSC lines could be used for a deeper study of filaminopathies.

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