FUME-TCRseq Enables Sensitive and Accurate Sequencing of the T-cell Receptor from Limited Input of Degraded RNA

FUME-TCRseq 能够从有限的降解 RNA 输入中对 T 细胞受体进行灵敏且准确的测序

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作者:Ann-Marie Baker, Gayathri Nageswaran, Pablo Nenclares, Tahel Ronel, Kane Smith, Christopher Kimberley, Miangela M Laclé, Shreerang Bhide, Kevin J Harrington, Alan Melcher, Manuel Rodriguez-Justo, Benny Chain #, Trevor A Graham #

Significance

FUME-TCRseq is a TCR sequencing methodology that supports sensitive and spatially resolved detection of TCR clones in archival clinical specimens, which can facilitate longitudinal tracking of immune responses through disease course and treatment.

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