Translational Activation of ATF4 through Mitochondrial Anaplerotic Metabolic Pathways Is Required for DLBCL Growth and Survival

通过线粒体补充代谢途径翻译激活 ATF4 是 DLBCL 生长和存活的必要条件

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作者：Meng Li, Matthew R Teater, Jun Young Hong, Noel R Park, Cihangir Duy, Hao Shen, Ling Wang, Zhengming Chen, Leandro Cerchietti, Shawn M Davidson, Hening Lin, Ari M Melnick

期刊：

Blood Cancer Discovery

影响因子：

11.500

时间：

2022

起止号：

2022 Jan;3(1):50-65.

doi：

10.1158/2643-3230.BCD-20-0183

研究方向：

代谢、信号转导

信号通路：

Translational Control

Significance

We discovered the link between SIRT3 and ATF4 in DLBCL cells, which connected lymphoma amino acid metabolism with ATF4 translation via metabolic stress signals. SIRT3-ATF4 axis is required in DLBCL cells regardless of subtype, which indicates a common metabolic vulnerability in DLBCLs and can serve as a therapeutic target.This article is highlighted in the In This Issue feature, p. 1.

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