Examination of the ovarian reserve after generation of unilateral rudimentary uterine horns in rats

对大鼠单侧残根子宫角形成后卵巢储备功能的检查

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Abstract

OBJECTIVE: The purpose of this experimental rat model study is to evaluate the changes in the ovarian environment after excision of the rudimentary horn. METHODS: Ten female Wistar albino rats were used in this study. One cm of right uterine horn length was excised in the first operation. Two months after the first operation, all animals were sacrificed to obtain ovaries for histological examination. Mann-Whitney U test and Student's t-test were used for statistical analysis purposes. Statistical significance was defined as P < 0.005. RESULTS: The number of primordial follicles (P = 0.415), primary follicles (P = 0.959), preantral follicles (P = 0.645), antral follicles (P = 0.328), and Graafian follicles (P = 0.721) was decreased and the number of atretic follicles (P = 0.374) increased in the right ovarian side. Howeve,r this difference was not found to be statistically significant. CONCLUSION: The results of this experimental rat model study suggest that the excision of rudimentary horn could have negative effects on ipsilateral ovarian functions.

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