Exploring Interrupted Nazarov Cyclizations Using Tethered Sulfonamide Nucleophiles: Insights into Capture Pathways

利用连接的磺酰胺亲核试剂探索中断的Nazarov环化反应:对捕获途径的深入理解

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Abstract

This manuscript describes a study of diverse reaction outcomes that stem from the ionization of aza-alkynyl-Prins adducts. Experimental results have demonstrated unexpected behavior in the nitrogen-containing systems compared to the analogous oxygen derivatives derived from oxa-Prins/halo-Nazarov sequences. In-depth experimental studies and computational analysis revealed an intricate mechanism involving competing halo-Nazarov and imino-Nazarov pathways. These findings further elucidate the reaction chemistry of 3-halo-pentadienyl cation intermediates, and expand their utility in synthetic transformations.

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