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Quaternary Carbon as a Locus for Skeletal Disconnection. Total Synthesis of (±)-Tubingensin A Featuring Assembly of the Backbone Stereotriad Using a Halo-Prins/Halo-Nazarov Cascade

季碳作为骨架断裂位点。利用Halo-Prins/Halo-Nazarov级联反应组装骨架立体三联体，实现(±)-Tubingensin A的全合成。

期刊:Journal of the American Chemical Society

影响因子:15.6

doi:10.1021/jacs.5c06475

Milosavljevic, Aleksa; Alachouzos, Georgios; Frontier, Alison J

信号转导

发表日期：2025

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Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition

通过抑制硬骨蛋白促进多发性骨髓瘤溶骨性病变愈合和骨骼健康恢复

期刊:Experimental Hematology & Oncology

影响因子:13.5

doi:10.1186/s40164-025-00699-4

Sabol, Hayley M; Anloague, Aric; Kaur, Japneet; Bustamante-Gomez, Cecile; Khan, Sharmin; Paxton, Bethany C; Nester, Mattie R; Hackney, Jillian; Diaz-delCastillo, Marta; Mann, Daniel; Stambough, Jeffrey B; Barnes, C Lowry; Ambrogini, Elena; Frontier, Alison; Ebetino, Frank H; Naqvi, Syed; van Rhee, Frits; Wardell, Christopher P; Drake, Matthew T; Nookaew, Intawat; Schinke, Carolina; Zangari, Maurizio; Delgado-Calle, Jesus

Advancing the implementation of artificial intelligence in regulatory frameworks for chemical safety assessment by defining robust readiness criteria

通过制定稳健的准备标准，推进人工智能在化学品安全评估监管框架中的应用。

期刊:Frontiers in Artificial Intelligence

影响因子:4.7

doi:10.3389/frai.2025.1738770

de Paula Souza, Joyce; Blum, Jonathan; Maran, Uko; Sild, Sulev; Dawson, Louis; Čavoški, Aleksandra; Holden, Laura; Lee, Robert; Karnel, Veronika; Meusburger, Lukas; Fraize-Frontier, Sandrine; Walsh, Alexander; Rivière, Gilles; Raitano, Giuseppa; Roncaglioni, Alessandra; Di Consiglio, Emma; Tcheremenskaia, Olga; Bossa, Cecilia; Wendt-Rasch, Lina; Puzyn, Tomasz; Fritsche, Ellen

发表日期：2025

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Alkynyl Halo-Prins Cyclizations for the Synthesis of Bicyclo[4.3.1] and [3.3.1] Oxygen-Bridged Heterocycles

炔基卤代Prins环化反应合成双环[4.3.1]和[3.3.1]氧桥杂环化合物

期刊:Journal of Organic Chemistry

影响因子:3.6

doi:10.1021/acs.joc.5c01745

Ibrahim, Yusuf A; Frontier, Alison J

发表日期：2025

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Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects

羟氯喹和一种低抗骨吸收活性的双膦酸盐缀合物通过双重抗骨吸收和合成代谢作用，预防和逆转小鼠卵巢切除术引起的骨丢失。

期刊:Bone Research

影响因子:15

doi:10.1038/s41413-024-00352-6

Yao, Zhenqiang; Ayoub, Akram; Srinivasan, Venkatesan; Wu, Jun; Tang, Churou; Duan, Rong; Milosavljevic, Aleksa; Xing, Lianping; Ebetino, Frank H; Frontier, Alison J; Boyce, Brendan F

代谢

发表日期：2024

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Mitigation of supply chain challenges in cell therapy manufacturing: perspectives from the cord blood alliance

缓解细胞疗法生产供应链挑战：来自脐带血联盟的视角

期刊:Stem Cells Translational Medicine

影响因子:4.9

doi:10.1093/stcltm/szae048

Killela, Patrick; Herrity, Kieran; Frontier, Ludwig; Horton, Roger; Kurtzberg, Joanne; Van't Hof, Wouter

细胞生物学

发表日期：2024

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Exploring Interrupted Nazarov Cyclizations Using Tethered Sulfonamide Nucleophiles: Insights into Capture Pathways

利用连接的磺酰胺亲核试剂探索中断的Nazarov环化反应：对捕获途径的深入理解

期刊:European Journal of Organic Chemistry

影响因子:2.7

doi:10.1002/ejoc.202400444

Milosavljevic, Aleksa; Hernandez, Jackson J; Zybura, Patrycia K; Frontier, Alison J

发表日期：2024

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Hydroxychloroquine and a low activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects

羟氯喹和低活性双膦酸盐缀合物通过双重抗吸收和合成代谢作用，预防和逆转小鼠卵巢切除术引起的骨丢失。

期刊:

影响因子:

doi:10.21203/rs.3.rs-4237258/v1

Yao, Zhenqiang; Ayoub, Akram; Srinivasan, Venkatesan; Wu, Jun; Tang, Churou; Duan, Rong; Milosavljevic, Aleksa; Ebetino, Frank; Frontier, Alison; Boyce, Brendan

代谢

发表日期：2024

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Nitrogen-interrupted halo-Prins/halo-Nazarov fragment coupling cascade for the synthesis of indolines

氮中断的卤代Prins/卤代Nazarov片段偶联级联反应用于合成吲哚啉

期刊:Chemical Science

影响因子:7.4

doi:10.1039/d3sc00986f

Milosavljevic, Aleksa; Holt, Connor; Frontier, Alison J

信号转导

发表日期：2023

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Cationic Cascade Strategy for the Synthesis of Dihydrobenzofuran and Isochromane Scaffolds

阳离子级联策略合成二氢苯并呋喃和异色满骨架

Quaternary Carbon as a Locus for Skeletal Disconnection. Total Synthesis of (±)-Tubingensin A Featuring Assembly of the Backbone Stereotriad Using a Halo-Prins/Halo-Nazarov Cascade

季碳作为骨架断裂位点。利用Halo-Prins/Halo-Nazarov级联反应组装骨架立体三联体，实现(±)-Tubingensin A的全合成。

Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition

通过抑制硬骨蛋白促进多发性骨髓瘤溶骨性病变愈合和骨骼健康恢复

Advancing the implementation of artificial intelligence in regulatory frameworks for chemical safety assessment by defining robust readiness criteria

通过制定稳健的准备标准，推进人工智能在化学品安全评估监管框架中的应用。

Alkynyl Halo-Prins Cyclizations for the Synthesis of Bicyclo[4.3.1] and [3.3.1] Oxygen-Bridged Heterocycles

炔基卤代Prins环化反应合成双环[4.3.1]和[3.3.1]氧桥杂环化合物

Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects

羟氯喹和一种低抗骨吸收活性的双膦酸盐缀合物通过双重抗骨吸收和合成代谢作用，预防和逆转小鼠卵巢切除术引起的骨丢失。

Mitigation of supply chain challenges in cell therapy manufacturing: perspectives from the cord blood alliance

缓解细胞疗法生产供应链挑战：来自脐带血联盟的视角

Exploring Interrupted Nazarov Cyclizations Using Tethered Sulfonamide Nucleophiles: Insights into Capture Pathways

利用连接的磺酰胺亲核试剂探索中断的Nazarov环化反应：对捕获途径的深入理解

Hydroxychloroquine and a low activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects

羟氯喹和低活性双膦酸盐缀合物通过双重抗吸收和合成代谢作用，预防和逆转小鼠卵巢切除术引起的骨丢失。

Nitrogen-interrupted halo-Prins/halo-Nazarov fragment coupling cascade for the synthesis of indolines

氮中断的卤代Prins/卤代Nazarov片段偶联级联反应用于合成吲哚啉