Abstract
Nutritional therapy is an essential supportive intervention for patients with COVID-19 who are at high nutritional risk, although the optimal timing for initiating nutritional support remains unclear. The present study investigated the association between the initiation of enteral nutrition (EN) and the incidence of refeeding syndrome (RS) in severely ill patients with COVID-19 and high nutritional risk. Patients from Tongji Hospital (Wuhan, China), with a Nutrition Risk Screening-2002 score ≥3 and who received EN, were retrospectively analyzed and categorized into an early EN (EEN) group and a late EN (LEN) group based on the time-frame of EN initiation. Serum electrolyte levels were assessed on the third day after EN initiation to evaluate the incidence of RS. A total of 211 patients were included in this analysis (EEN group, n=125; LEN group, n=86). The mean time to EN initiation was 2 days in the EEN group and 5 days in the LEN group. Both the incidence and severity of RS were markedly higher in the LEN group, and serum potassium, sodium, phosphorus and magnesium levels were significantly lower in the LEN group on the third day after EN initiation. These findings suggest that early EN initiation may help reduce the risk of RS in critically ill patients with COVID-19 and high nutritional risk.