Synthesis of cyclic ethers by cyclodehydration of 1,n-diols using heteropoly acids as catalysts

以杂多酸为催化剂,通过1,n-二醇的环脱水反应合成环醚

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Abstract

Heteropoly acids were used as catalysts for cyclodehydration of various 1,n-diols. Cyclodehydration of butane-1,4-diol, pentane-1,5-diol and hexane-1,6-diol catalysed by H(3)PW(12)O(40) gave tetrahydrofuran, tetrahydropyran and oxepane, respectively. Cyclodehydration of diethylene glycol, triethylene glycol, diethylene glycol monomethyl ether and polyethylene glycol 200 catalysed by H(3)PW(12)O(40) gave 1,4-dioxane. In particular, cyclodehydration of hexane-1,6-diol gave an excellent yield of oxepane (80%). The selectivity exhibited by the H(3)PW(12)O(40) catalyst was even better than that exhibited by other reported catalyst systems for similar cyclodehydration reactions.

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