Derivation of iPSC lines from three young healthy donors of Caucasian origin (NUIGi035-A; NUIGi036-A; NUIGi037-A)

从三名白种人年轻健康捐赠者体内衍生出 iPSC 系 (NUIGi035-A;NUIGi036-A;NUIGi037-A)

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作者:Yicheng Ding, Berta Marcó de la Cruz, Veronica McInerney, Yin Lu, Guangming Yang, Xiaohong Qian, Weidong Li, Janusz Krawczyk, Linda Howard, Timothy O'Brien, Louise Gallagher, Sanbing Shen

Abstract

The induced pluripotent stem cell (iPSC) technology has offered an unprecedented opportunity for disease modelling and drug discovery. Here we used non-integrating Sendai viral method and derived iPSCs from three young healthy Caucasian donors. All iPSCs expressed pluripotency markers highly and could be differentiated into three germ lineages. They possess normal karyotype which was confirmed by whole genome SNP array. The availability of the healthy control iPSCs offers an opportunity for phenotypic comparison and genome editing for a variety of diseases.

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