Abstract
The RNA modification of N(6)-methyladenosine (m(6)A) controls many aspects of RNA function that impact biological processes, including viral infection. In this review, we highlight recent work that shapes our current understanding of the diverse mechanisms by which m(6)A can regulate viral infection by acting on viral or cellular mRNA molecules. We focus on emerging concepts and understanding, including how viral infection alters the localization and function of m(6)A machinery proteins, how m(6)A regulates antiviral innate immunity, and the multiple roles of m(6)A in regulating specific viral infections. We also summarize the recent studies on m(6)A during SARS-CoV-2 infection, focusing on points of convergence and divergence. Ultimately, this review provides a snapshot of the latest research on m(6)A during viral infection.