Lymphadenopathy driven by TCR-V(γ)8V(δ)1 T-cell expansion in FAS-related autoimmune lymphoproliferative syndrome

FAS-dependent apoptosis in V(δ)1 T cells makes the latter possible culprits for the lymphadenopathy observed in patients with FAS mutations.Rapamycin and methylprednisolone resistance should prompt clinicians to look for V(δ)1 T cell proliferation in ALPS-FAS patients.