Abstract
Glycogenic acanthosis (GA) is a benign, asymptomatic condition commonly found in the lower third of the esophagus. This case report presents a unique occurrence of GA on the lips of a 55-year-old male smoker, who exhibited asymptomatic white lesions on his upper and lower lips for many years. Physical examination revealed multiple white papules on the wet-dry vermilion border of the lips. Biopsies confirmed the diagnosis of GA, showing acanthosis, hyperkeratosis, and glycogenesis without dysplasia. The rarity of GA on the lips underscores the need to consider it in the differential diagnosis of white papules on the lips. This report is the first to document GA's histopathological features on the lips, highlighting its potential occurrence in atypical sites.