Abstract
The general claim about novel molecularly imprinted polymers is that they are selective for their template or for another target compound. This claim is usually proved by some kind of experiment, in which a performance parameter of the imprinted polymer is shown to be better towards its template than towards interferents. A closer look at such experiments shows, however, that different experiments may differ substantially in what they tell about the same imprinted polymer's selectivity. Following a short general discussion of selectivity concepts, the selectivity of imprinted polymers is analyzed in batch adsorption, binding assays, chromatography, solid phase extraction, sensors, membranes, and catalysts. A number of examples show the problems arising with each type of application. Suggestions for practical method design are provided.