Calcium Fluxes in Work-Related Muscle Disorder: Implications from a Rat Model

工作相关性肌肉疾病中的钙通量:来自大鼠模型的启示

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作者:J Hadrevi, M F Barbe, N Ørtenblad, U Frandsen, E Boyle, S Lazar, G Sjøgaard, K Søgaard

Discussion

These disturbances may mirror intracellular changes in early stages of human work-related myalgic muscle. Increased uptake of Ca2+ into the SR may reflect an early adaptation to avoid a sustained detrimental increase in [Ca2+]i similar to the previous findings of deteriorated Ca2+ regulation and impaired function in fatigued human muscle.

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