Pre-targeting and direct immunotargeting of liposomal drug carriers to ovarian carcinoma

脂质体药物载体对卵巢癌的预定向和直接免疫靶向

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作者:Julia Lehtinen, Mari Raki, Kim A Bergström, Päivi Uutela, Katariina Lehtinen, Annukka Hiltunen, Jere Pikkarainen, Huamin Liang, Sari Pitkänen, Ann-Marie Määttä, Raimo A Ketola, Marjo Yliperttula, Thomas Wirth, Arto Urtti

Background

Epidermal growth factor receptor (EGFR) is overexpressed in many solid tumor types, such as ovarian carcinoma. Immunoliposome based drug targeting has shown promising

Significance

Intraperitoneal administration of liposomes may be a beneficial approach to treat the tumors in the abdominal cavity. The i.p. pre-targeting method warrants further studies as a potential approach in cancer therapy.

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