Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib

BCR::ABL1中ABL1外显子2编码的SH3残基的缺失会破坏自身抑制的激酶构象，并赋予其对阿西米尼的耐药性。