Abstract
Although there has been research on the toxicity of Rhizoma Paridis (Chong Lou), a systematic and comprehensive evaluation, as well as targeted strategies for mitigating its toxicity, remains lacking. This review aims to provide a thorough assessment of the toxicological properties of Rhizoma Paridis, offering reliable guidance for its safe application. The article focuses on the toxicity and underlying mechanisms of Rhizoma Paridis and reviews the applications of both traditional Chinese medicine and modern scientific technologies in detoxification. Finally, it proposes future research directions, emphasizing the need for further exploration of chronic toxicity mechanisms and advocating for the integration of traditional and modern detoxification methods to ensure the safe clinical use of Rhizoma Paridis. This review provides the latest theoretical foundation for the safe use and further development of Rhizoma Paridis.