Aseptic Sinusitis: A New Phenotype of Immune-Related Rhinosinusitis in the Era of Immune Checkpoint Inhibitors

We present two novel cases of aseptic sinusitis resulting from PDL-1 checkpoint inhibitor use. Prompt identification and diagnosis and a multidisciplinary approach with oncology and rheumatology are imperative. High-dose steroids are preferable to antibiotics or antihistamines due to primary cancer treatment outcomes.