Abstract
A simple and novel method to analyse the centration of a lenticule of tissue extracted from a cornea has been developed, in which the centre of "mass" of the individual differences between post and preoperative maps of several corneal metrics represents the lenticule centration and its spatial distance to a reference point (aimed centration) determines the decentration. Different parameters have been evaluated to weight the centre of "mass". The robustness of the methods has been evaluated using perturbation analysis (adding white-noise to the data) based on realistic uncertainties. A clipped analysis has been performed to prevent large, localised areas of lacking/missing data from affecting the centre of "mass". The method has been tested on a pilot cohort of clinical data showing 30% and 63% of the treatments within 200 µm of decentration for corneal thickness and refractive equivalent power, respectively. Except for anterior elevation with a total standard deviation of 17 µm, all other metrics show excellent precision of ∼5 µm. The method provides a reliable and objective way to determine the centration of a lenticule of tissue extracted from a cornea and it can be applied to any topo- or tomographic derived metric.