Abstract
This case report presents a rare clinical manifestation of uterine spindle cell sarcoma, an aggressive and uncommon malignancy, in a 79-year-old female patient. The patient presented with lower gastrointestinal (GI) bleeding, constipation, and significant weight loss. Colonoscopy identified an infiltrative, ulcerated mass within the sigmoid colon, later confirmed by biopsy as a high-grade spindle cell sarcoma of uterine origin. Given the unresectable status of the mass, chemotherapy was initiated as the primary treatment. This report discusses the diagnostic challenges and highlights the importance of considering atypical presentations in patients with lower GI bleeding and weight loss.