日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A physiologically-relevant intermediate state structure of a voltage-gated potassium channel

电压门控钾通道的生理相关中间态结构

Kyriakis, Efthimios; Sastre, Daniel; Eldstrom, Jodene; Roscioni, Agnese; Russo, Sophia; Ataei, Fariba; Dou, Ying; Chan, Magnus; Molinarolo, Steven; Maragliano, Luca; Van Petegem, Filip; Fedida, David

The conductance of KCNQ2 and its pathogenic variants is determined by individual subunit gating.

KCNQ2 及其致病变体的电导是由各个亚基的门控决定的

Hinojo-Perez Andy, Eldstrom Jodene, Dou Ying, Marinho-Alcara Allan, Edmond Michaela A, de la Cruz Alicia, Perez Rodriguez Marta E, Diaz-Solares Maykelis, Dykxhoorn Derek M, Fedida David, Barro-Soria Rene

Graded activation of mutant K41C-KCNE1:KCNQ1 channel complexes by mefenamic acid

甲芬那酸对突变型 K41C-KCNE1:KCNQ1 通道复合物的梯度激活

Wang, Yundi; Chan, Magnus; Pourrier, Marc; Eldstrom, Jodene; Fedida, David

Electrophysiological characterization of the state-dependent inhibition of Kv7.1 and I(Ks) by UCL2077

UCL2077 对 Kv7.1 和 I(Ks) 的状态依赖性抑制的电生理特性研究

Sastre, Daniel; Kyriakis, Efthimios; Schauer, Julia; Chan, Magnus; Dou, Ying; Eldstrom, Jodene; Fedida, David

Uterine Spindle Cell Sarcoma Presenting With Lower Gastrointestinal Bleeding: A Case Report

子宫梭形细胞肉瘤伴下消化道出血:病例报告

Habbas, Ahmad; Althunibat, Ismail; Elemian, Shatha; Okwesili, Byron; Abiola, Abdul Aishat; Sorour, Laith; Al Radaideh, Amro; Fedida, Andre

BORIS/CTCFL epigenetically reprograms clustered CTCF binding sites into alternative transcriptional start sites

BORIS/CTCFL 通过表观遗传学方法将聚集的 CTCF 结合位点重编程为替代的转录起始位点

Elena M Pugacheva, Dharmendra Nath Bhatt, Samuel Rivero-Hinojosa, Md Tajmul, Liron Fedida, Emma Price, Yon Ji, Dmitri Loukinov, Alexander V Strunnikov, Bing Ren, Victor V Lobanenkov

Ion permeation through a narrow cavity constriction in KCNQ1 channels: Mechanism and implications for pathogenic variants

KCNQ1通道中离子通过狭窄腔隙的渗透:机制及其对致病变异的影响

Mkrtchyan, Liana; Sahakyan, Harutyun; Eldstrom, Jodene; Karapetyan, Tatev; Abrahamyan, Astghik; Nazaryan, Karen; Schwarz, Jürgen R; Kneussel, Matthias; Fedida, David; Vardanyan, Vitya

PUFA stabilizes a conductive state of the selectivity filter in IKs channels

多不饱和脂肪酸(PUFA)可稳定IK通道中选择性过滤器的导电状态。

Golluscio, Alessia; Eldstrom, Jodene; Jowais, Jessica J; Perez, Marta Elena; Cunningham, Kevin Peter; De La Cruz, Alicia; Wu, Xiaoan; Corradi, Valentina; Tieleman, D Peter; Fedida, David; Larsson, H Peter

Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors

利用突变电压传感器评估 IKs 通道的顺序激活和变构激活模型

Fedida, David; Sastre, Daniel; Dou, Ying; Westhoff, Maartje; Eldstrom, Jodene

A generic binding pocket for small molecule IKs activators at the extracellular inter-subunit interface of KCNQ1 and KCNE1 channel complexes

KCNQ1 和 KCNE1 通道复合物细胞外亚基间界面处的小分子 IKs 激活剂的通用结合口袋

Magnus Chan #, Harutyun Sahakyan #, Jodene Eldstrom #, Daniel Sastre, Yundi Wang, Ying Dou, Marc Pourrier, Vitya Vardanyan, David Fedida