Abstract
Hot taste spices have enormous health benefits starting from kitchen to pharmaceutical laboratories. Our present study is focused on phytochemical and pharmacological screening of six hot taste spices namely Zingiber officinale (ginger), Capsicum annuum (chilli), Piper chaba (java long pepper), Piper nigrum (black pepper), Syzygium aromaticum (clove), Trachyspermum ammi (carom). Among all six spices, clove and ginger exhibited strong antioxidant activity owing to higher phytochemical contents. Significant antifungal activity (IZD ≥ 11 mm) was revealed by all six spices except hexane fraction of carom whereas strong antibacterial activity with lowest MIC was displayed by clove, ginger and chilli. DNA was successfully protected from oxidative damage by clove, ginger followed by chilli, java long pepper and carom but black pepper could only partially protect DNA damage even at 4 mg/ml concentration. Based on the DNA damage protecting potentials and antioxidant activities clove, ginger, java long pepper and carom may be utilized for neutraceuticals development. Antimicrobial activities suggested that clove, ginger, java long pepper and chilli may be useful as food preservatives. Fractionated bioactivity of the all the six HTS would help for targeted extraction and development of nutraceuticals from these commonly used medicinal spices.